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WSMR's investigators have designed
a synthetic peptide that activates an
obscure receptor that sits on the surface
of a patient's own hair follicle cells.
This peptide was then used to activate
the patient's hair follicles into growth
phase.
The study demonstrates that it is possible
to get the human hair follicle to recognize
a synthetic peptide and the message
from that peptide. The synthetic peptide
sequence is called Flexible Peptide
S (FLEX S) and is named due to its flexible
binding characteristics on the hair
follicle cells.
There are currently two separate sequences
of FLEX S, both of which switch the
hair follicle into growth phase.
"It now appears that we can restore
all of the follicles on the scalp to
a healthy condition, the implications
are profound" said Slobodan Jankovic,
M.D., Ph.D., Director of the Centre
for Clinical and Experimental Pharmacology,
Dean of Medical Faculty, University
of Kragujevac Yugoslavia and Scientific
advisor to WSMR.
Jankovic went on to say "This
indicates that even in slick balding
areas of the scalp the follicles are
just miniaturized and can be switched
back on with the right synthetic peptide
messenger."
All of the patients received a topical
mixture containing the designer peptide
(FLEX S) and a special liposome like
adjuvant to enhance its uptake by the
hair follicle.
"Safety isn't a problem, because
the peptide is too large to get from
the scalp into systemic circulation.
It is almost like nature intended this
peptide to induce hair re-growth and
not get to the rest of the body."
Said S.L (Bob) Hsia, Ph.D. Professor
of Dermatology & Cutaneous Surgery,
liposome and skin biology expert from
the University of Miami School of Medicine.
Dr. Hsia who also is a scientific advisor
to WSMR, went on to say "The special
design of the topical vehicle to take
the FLEX S peptide to the hair follicle
is key to the effectiveness."
"This synthetic peptide is amazing,
it acts just like a "hair switch"
turning on the follicles and making
them begin growing hair again."
Commented John Emerson, M.D. a practicing
plastic surgeon and member of the SAB
of WSMR.
But Darren Green, Press consultant
for WSMR Cautioned, "Yes, it does
appear that we have found a safe and
completely effective treatment for hair
loss, but constructing complex synthetic
peptides like FLEX S 1 & 2 is currently
very expensive. The product could not
become commercially available until
the cost can be reduced from the current
level of almost $500 per month."
For more information about FLEX S and
other synthetic peptides that induce
hair growth visit WSMR's Website for
patients, public and the mass media
at http://www.hairswitch.com
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